Endocannabinoid System and CBD – How It Works

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In This Article

Our bodies work around the clock to maintain our well-being. From organ health right down to our cells, it never stops. We take a closer look at the endocannabinoid system and CBD to find out if it could help maintain homeostasis.

RELATED: What Are The Most Common Cannabinoids Found In Hemp?

Endocannabinoid System and CBD: What Is Homeostasis?

Homeostasis is the body’s way of self-regulating its internal environment. It relies on other systems, such as the Endocannabinoid system, to function and maintain your health.

Here are some examples of homeostasis at work in your body:


Imagine a trip to the beach or a walk on a crisp winter morning if you could not regulate your body temperature. Homeostasis ensures that you sweat when you are too hot and shiver when you are too cold. It’s vital to maintain your internal temperature to maintain good health.


Nobody enjoys suffering a bout of food poisoning. When you feel sweaty and nauseous, that’s your body’s homeostasis recognizing a threat to your health and working to eliminate it from causing organ or cellular damage.

Homeostasis also tells your pancreas to produce insulin to keep your glucose levels balanced.


Your body is working hard to maintain sufficient water to keep you alive at a cellular level. Homeostasis controls both the urinary system and the urge to drink. It can direct fluids where they need to go to maintain digestive and organ health.

What Is the Endocannabinoid System?

Aside from insects, almost all plants and animals have an ECS. Your Endocannabinoid system produces molecules as needed to help maintain homeostasis.

Hemp plants contain CBD ( plant cannabinoid molecules) and are thought to explain the potential therapeutic effects of CBD on the human endocannabinoid system.

The endocannabinoid system ( ECS) has two known receptors:

  • CB1 – primarily located in the brain and nervous system.
  • CB2 – primarily in the immune and digestive tissue.

It’s thought that the ECS has more receptors yet to be discovered.

ECS has a significant influence on:

  • Reducing Inflammation 
  • Controlling Anxiety
  • Controlling Appetite 
  • Controlling Sleep Cycles
  • Reducing Stress

How Does the Endocannabinoid System Work?

An excellent example of ECS working is how it deals with stress and inflammation.


When your body experiences stress, it releases stress chemicals. Cortisol is the chemical responsible for the ‘fight or flight’ response to perceived dangers. 

When we become stressed or anxious, cortisol floods our brain raising adrenaline levels. While this function is vital to keep us safe, it can become an automatic response to any trigger of stress, real or imagined, over time. 

This can lead to prolonged, anxious feelings and affect sleep and appetite.

Your Endocannabinoid system reacts to cortisol production by switching on its receptors to produce molecules that have a dampening effect and will reduce the level of cortisol produced by switching off the ‘fight or flight’ response. 

Over time your brain learns to maintain this cortisol dampening. However, if your ECS is not learning to switch off stress, you can suffer from prolonged anxiety.


Your ECS can instruct it’s receptors in the nervous system to reduce inflammation. It’s also understood to influence peripheral nerve distress.

What Is the Link Between the Endocannabinoid System and CBD?

If your ECS cannot reduce stresses in your body, it may result in unwanted stress, both mental and physical. 

CBD is a plant molecule that is similar to your body’s ECS molecules. While it’s not yet understood how it signals the body to active ECS receptors, it’s thought that it may bind to an as yet undiscovered receptor.

The studies on fully understanding how and why our bodies react to CBD, and its therapeutic potentials, are currently carried out in labs across the globe. The science is in its infancy, but reports on its potential health benefits are being published daily.

Endocannabinoid System and CBD: Good to Know

If you are currently taking any medications, discuss with your doctor before taking any CBD product as it may interact with your medicine. If you have been advised to avoid grapefruit while taking medication, you should not take CBD. 

CBD has the potential to help you maintain good health by assisting your body in regulating homeostasis through the ECS system. We provided a range of products to help you on your journey to good health. 


Do you have a favorite CBD product? Comment below and tell us about how you discovered the benefits of CBD.

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